The overall goal of our research is to develop novel mathematical models and computational/statistical tools to investigate the molecular and sub-cellular mechanisms of complex cardiovascular diseases such as heart failure, atrial fibrillation, sick sinus syndrome, hypertension, and diabetes.

A common theme of our research is in utilizing these computational frameworks to quantitatively assess the role and crosstalk of ion homeostasis and intracellular signaling pathways in health and disease. We leverage this understanding to identify therapeutic targets, inform treatment strategies, and predict the outcome of pharmacological treatment.

Specific research areas include: