The overall goal of our research is to develop novel mathematical models and computational/statistical tools to investigate the molecular and sub-cellular mechanisms of complex cardiovascular diseases such as heart failure, atrial fibrillation, sick sinus syndrome, hypertension, and diabetes.
A common theme of our research is in utilizing these computational frameworks to quantitatively assess the role and crosstalk of ion homeostasis and intracellular signaling pathways in health and disease. We leverage this understanding to identify therapeutic targets, inform treatment strategies, and predict the outcome of pharmacological treatment.
Specific research areas include:
Dysregulation of ventricular excitation-contraction coupling in heart failure
Effect of sex differences on cardiac electrophysiology and pharmacology
Inter-subject variability and patient-specific therapeutic approaches
Mechanisms and treatments for supraventricular arrhythmias
Regulation of contractility in vascular smooth muscle cells